NEUROECTODERMAL TUMOURS OF THE CENTRAL AND PERIPHERAL NERVOUS SYSTEM

Expression of Apo-3 and Apo-3L in primitive neuroectodermal tumours of the central and peripheral nervous system.

Deregulation of apoptosis has been implicated in the pathogenesis, spontaneous regression and treatment resistance of neuroblastoma. A newly recognised member of the tumour necrosis factor (TNF)-family of death receptors known as Apo-3 has been mapped to human chromosome 1p36.3, a region commonly deleted in aggressive neuroblastoma. Based on its localisation and function, Apo-3 is a candidate f...

Tumours of the central nervous system.

Embryonic tumours of the central nervous system.

ADENOSINE IN THE CENTRAL NERVOUS SYSTEM

Besides being a metabolite of nucleotides like ATP, adenosine is a mediator of neuronal function in the central nervous system. Its actions are mediated by at least three extracellular receptors. In this review different aspects of adenosine such as biosynthesis, release, inactivation and its receptors are discussed. It also covers pre- and postsynaptic effects as well as postreceptor mecha...

The Diagnosis of Tumours of the Central Nervous System

This paper is concerned with the clinical diagnosis of tumours of the central nervous system : the pure clinical investigation which from long practice has come to include certain of the special methods, ophthalmoscopy, perimetry and lumbar puncture. Although the only true symptom of a tumour of the central nervous system is progressive loss of neurological function, gradual and of varying pace...